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Gains in Bulk

Can Creatine and Caffeine Be Taken Together?

Supplement stacking has gained much attention for its practicality in providing the body with essential nutrients. Two top-rated supplements, creatine and caffeine, are often used together. Each supplement offers distinct advantages – creatine increases muscle power and stamina, while caffeine boosts alertness and endurance.


However, taking them at the same time might nullify their respective benefits - or at least according to the word of what some studies reveal. Let’s discuss the potential pros and cons of taking creatine and caffeine together and what the research says. It's crucial to emphasize that seeking professional advice before starting a new supplement routine is not just a suggestion but a necessary step to ensure your health and safety.


Remember, your body is unique, and what works for others may not always work or be the best for you.

scoop on spilled creatine

The Purported Negative Interaction of Creatine and Caffeine Being Taken Together


According to certain investigations, combining creatine with caffeine might cancel out creatine’s advantages, although more research is needed to reach a definitive answer. Taking creatine alone elevates levels of phosphocreatine in muscle tissues and enhances performance during high-intensity workouts; however, a study shows that these benefits disappeared when both substances were ingested together - arguing an adverse interaction in which caffeine nullifies the positive effects of creatine. This potential risk should be taken into consideration when planning your supplement routine.


The results showed that creatine supplementation increased muscle PCr concentration by 4-6% and improved dynamic torque production by 10-23%. However, when combined with caffeine, the ergogenic effect of creatine was eliminated.


This proposed interaction between caffeine and creatine may be due to their opposite effects on muscle relaxation time. Caffeine tends to prolong muscle relaxation time, which might negate the beneficial effects of creatine on muscle contraction.

A study further answers this by examining how taking creatine and caffeine supplements affects muscle function in healthy men. The men did leg exercises with electrical stimulation after taking creatine, caffeine, a combination of both, just caffeine, or a placebo. The results showed that creatine shortened the time for muscles to relax by 5% compared to the placebo, while caffeine made muscle relaxation time 10% longer. Combining creatine and caffeine or taking caffeine without creatine didn't significantly affect muscle relaxation time. The maximum muscle strength and the time it takes for the muscles to contract remained the same in all the different situations. The study concluded that caffeine makes muscles take longer to relax, which cancels out the effect of creatine on muscle relaxation time.


What about the potential synergy between the two supplements when stacked? More on that below. 

man lifting a dumbbell on the ground

Synergistic Effects of Taking Creatine and Caffeine Together


Those loudest about the benefits of stacking creatine and caffeine hail its ability decrease the rate of perceived exertion , which allows athletes across nearly every sport to push harder and longer. Combining the two together could cause you to feel less fatigued during intense workouts.


Some studies have even examined pre-workout supplements containing both creatine and caffeine, along with other ingredients like B vitamins and beta-alanine. This combination has been shown to improve muscular endurance and perceived energy during workouts. For instance, research on a mix of creatine, caffeine, and amino acids suggested it effectively enhanced anaerobic performance.


Additionally, a study on sprinters found that five days of creatine loading followed by caffeine intake improved peak power production more than creatine alone. This suggests that under certain loading and timing strategies, the combination can contribute to enhanced performance.

man sitting next to bad of instantized creatine in a gym

Should You Take Creatine and Caffeine Together?


Taken by themselves, creatine and caffeine have been proven to provide performance benefits for the casual gym goer to the dedicated bodybuilder.


However, the research regarding the combination of the two supplements presents a mixed bag of results. Some studies indicate that combining creatine and caffeine might negate the benefits of creatine. However, other research highlights possible synergistic effects, showing improvements in perceived exertion and peak power production when both supplements are used together under specific conditions.


The key takeaway here is that while the combination of creatine and caffeine might offer enhanced performance for some, it could also prove ineffective or even counterproductive for others. This underscores the importance of personalizing your supplement routine, really listening to your body, and consulting with a professional before making any changes.

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